E-ISSN 1858-8360 | ISSN 0256-4408
 

Original Research (Original Article) 


Carotid intima media thickness in children with nephrotic syndrome: an observational case control study

Anita Mehta, Shambhavi Mishra, Kaleem Ahmad, Harish Chandra Tiwari, Vijay Singh, Abhishek Singh.

Abstract
Carotid intima media thickness (cIMT) is considered as a surrogate marker for the various cardiovascular events that complicate nephrotic syndrome (NS). The present work was conducted to study cIMT in children with NS and to find out its correlation with dyslipidemia and other risk factors. This was a case control study conducted at a tertiary care hospital in children with NS who were more than 2 years with normal serum complement, being on therapy for NS for at least 1 year, glomerular filtration rate more than 90 ml/minute/1.73 m2 and absence of acute infection in previous 3 months. Sixty six children with NS constituted the case material and 128 age and sex matched children were taken as control. The mean age in case and control cohort was 6.71 3.3 and 7.89 3.95 years, respectively. The mean age of onset of illness was 4.32 2.25 years. The mean duration of illness was 2.39 1.44 years. Thickness of cIMT was higher in NS children as compared to control group in all the ages, but this difference was statistically significant only after 4 years of age. There was statistically significant, but weak positive correlation between cIMT and age of NS children, duration of disease and number of relapses. There was no correlation of cIMT with hypertension, body mass index, serum creatinine, and dyslipidemia. A negative, but statistically insignificant correlation of cIMT was found with serum albumin and serum cholesterol.

Key words: Carotid intimal-medial thickness; Nephrotic syndrome; Children; Dyslipidemia; Hypertension; Body mass index.


 
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How to Cite this Article
Pubmed Style

Mehta A, Mishra S, Ahmad K, Tiwari HC, Singh V, Singh A, . Carotid intima media thickness in children with nephrotic syndrome: an observational case control study. Sudan J Paed. 2019; 19(2): 110-116. doi:10.24911/SJP.106-1535804613


Web Style

Mehta A, Mishra S, Ahmad K, Tiwari HC, Singh V, Singh A, . Carotid intima media thickness in children with nephrotic syndrome: an observational case control study. http://www.sudanjp.com/?mno=6218 [Access: March 28, 2020]. doi:10.24911/SJP.106-1535804613


AMA (American Medical Association) Style

Mehta A, Mishra S, Ahmad K, Tiwari HC, Singh V, Singh A, . Carotid intima media thickness in children with nephrotic syndrome: an observational case control study. Sudan J Paed. 2019; 19(2): 110-116. doi:10.24911/SJP.106-1535804613



Vancouver/ICMJE Style

Mehta A, Mishra S, Ahmad K, Tiwari HC, Singh V, Singh A, . Carotid intima media thickness in children with nephrotic syndrome: an observational case control study. Sudan J Paed. (2019), [cited March 28, 2020]; 19(2): 110-116. doi:10.24911/SJP.106-1535804613



Harvard Style

Mehta, A. ., Mishra, S. ., Ahmad, K. ., Tiwari, H. C., Singh, V. ., Singh, A. . . & (2019) Carotid intima media thickness in children with nephrotic syndrome: an observational case control study. Sudan J Paed, 19 (2), 110-116. doi:10.24911/SJP.106-1535804613



Turabian Style

Mehta, Anita , Shambhavi Mishra, Kaleem Ahmad, Harish Chandra Tiwari, Vijay Singh, Abhishek Singh, and . 2019. Carotid intima media thickness in children with nephrotic syndrome: an observational case control study. Sudanese Journal of Paediatrics, 19 (2), 110-116. doi:10.24911/SJP.106-1535804613



Chicago Style

Mehta, Anita , Shambhavi Mishra, Kaleem Ahmad, Harish Chandra Tiwari, Vijay Singh, Abhishek Singh, and . "Carotid intima media thickness in children with nephrotic syndrome: an observational case control study." Sudanese Journal of Paediatrics 19 (2019), 110-116. doi:10.24911/SJP.106-1535804613



MLA (The Modern Language Association) Style

Mehta, Anita , Shambhavi Mishra, Kaleem Ahmad, Harish Chandra Tiwari, Vijay Singh, Abhishek Singh, and . "Carotid intima media thickness in children with nephrotic syndrome: an observational case control study." Sudanese Journal of Paediatrics 19.2 (2019), 110-116. Print. doi:10.24911/SJP.106-1535804613



APA (American Psychological Association) Style

Mehta, A. ., Mishra, S. ., Ahmad, K. ., Tiwari, H. C., Singh, V. ., Singh, A. . . & (2019) Carotid intima media thickness in children with nephrotic syndrome: an observational case control study. Sudanese Journal of Paediatrics, 19 (2), 110-116. doi:10.24911/SJP.106-1535804613





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