E-ISSN 1858-8360 | ISSN 0256-4408
 

Review Article 


Inborn errors of metabolism associated with hyperglycaemic ketoacidosis and diabetes mellitus: narrative review

Majid Alfadhel, Amir Babiker.

Cited by (1)

Abstract
Inborn errors of metabolism (IEM) are heterogeneous group of disorders that might present in the clinics or emergency departments in different phenotypes, and one of these is a diabetes scenario. Diabetes is the most common endocrine disorder among children. The mechanism of how IEM could lead to diabetes is unclear; however, the postulated pathogenesis consists of three mechanisms: 1) accumulation of toxic substance in the gland, ruining structure and normal functionality, 2) disturbing energy availability required for hormone synthesis and 3) defect of complex molecules. The differential diagnosis of IEM associated with hyperglycaemic ketoacidosis and diabetes include: organic acidemias specifically propionic acidemia, methylmalonic acidemia, isovaleric acidemia, hereditary hemochromatosis, aceruloplasminemia, holocarboxylase synthetase deficiency, β-ketothiolase deficiency and finally, cystinosis, Rogers syndrome (thiamine-responsive megaloblastic anaemia) and congenital disorders of glycosylation type Ia. Clinical approach will help in ready diagnosis and treatment for IEM disorders in early detection of diabetes. In this review, we will discuss the differential diagnosis, clinical features and diagnostic approaches of IEM presenting as hyperglycaemic ketoacidosis and diabetes.

Key words: Aceruloplasminemia; Congenital disorders of glycosylation; Cystinosis; Diabetes mellitus; Hemochromatosis; Inborn errors of metabolism; Mitochondrial disorders; Organic aciduria; Rogers syndrome.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Majid Alfadhel
Articles by Amir Babiker
on Google
on Google Scholar
Article Statistics
 Viewed: 2425
Downloaded: 725
Cited: 1


This Article Cited By the following articles

Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults
Front. Psychiatry 2019; 10(): .

1
 
How to Cite this Article
Pubmed Style

Alfadhel M, Babiker A. Inborn errors of metabolism associated with hyperglycaemic ketoacidosis and diabetes mellitus: narrative review. Sudan J Paed. 2018; 18(1): 10-23. doi:10.24911/SJP.2018.1.3


Web Style

Alfadhel M, Babiker A. Inborn errors of metabolism associated with hyperglycaemic ketoacidosis and diabetes mellitus: narrative review. http://www.sudanjp.com/?mno=297820 [Access: October 17, 2019]. doi:10.24911/SJP.2018.1.3


AMA (American Medical Association) Style

Alfadhel M, Babiker A. Inborn errors of metabolism associated with hyperglycaemic ketoacidosis and diabetes mellitus: narrative review. Sudan J Paed. 2018; 18(1): 10-23. doi:10.24911/SJP.2018.1.3



Vancouver/ICMJE Style

Alfadhel M, Babiker A. Inborn errors of metabolism associated with hyperglycaemic ketoacidosis and diabetes mellitus: narrative review. Sudan J Paed. (2018), [cited October 17, 2019]; 18(1): 10-23. doi:10.24911/SJP.2018.1.3



Harvard Style

Alfadhel, M. & Babiker, . A. (2018) Inborn errors of metabolism associated with hyperglycaemic ketoacidosis and diabetes mellitus: narrative review. Sudan J Paed, 18 (1), 10-23. doi:10.24911/SJP.2018.1.3



Turabian Style

Alfadhel, Majid, and Amir Babiker. 2018. Inborn errors of metabolism associated with hyperglycaemic ketoacidosis and diabetes mellitus: narrative review. Sudanese Journal of Paediatrics, 18 (1), 10-23. doi:10.24911/SJP.2018.1.3



Chicago Style

Alfadhel, Majid, and Amir Babiker. "Inborn errors of metabolism associated with hyperglycaemic ketoacidosis and diabetes mellitus: narrative review." Sudanese Journal of Paediatrics 18 (2018), 10-23. doi:10.24911/SJP.2018.1.3



MLA (The Modern Language Association) Style

Alfadhel, Majid, and Amir Babiker. "Inborn errors of metabolism associated with hyperglycaemic ketoacidosis and diabetes mellitus: narrative review." Sudanese Journal of Paediatrics 18.1 (2018), 10-23. Print. doi:10.24911/SJP.2018.1.3



APA (American Psychological Association) Style

Alfadhel, M. & Babiker, . A. (2018) Inborn errors of metabolism associated with hyperglycaemic ketoacidosis and diabetes mellitus: narrative review. Sudanese Journal of Paediatrics, 18 (1), 10-23. doi:10.24911/SJP.2018.1.3





Most Viewed Articles
  • Rheumatic heart disease in North Darfur: an alarmingly high burden and control initiative
    Nagwa Salih, Ishag Eisa, Daresalam Ishag, Intisar Ibrahim, Sulafa Ali
    Sudan J Paed. 2018; 18(1): 24-27
    » Abstract » doi: 10.24911/SJP.2018.1.4

  • Evaluation of Science. [eng]
    Adnan Mahmmood Usmani; Sultan Ayoub Meo
    Sudan J Paed. 2011; 11(1): 6-7
    » Abstract

  • Blood tests are not always helpful in predicting bacterial meningitis in children.
    Taha I Yousif, Katie O'Reilly, Montasser Nadeem
    Sudan J Paed. 2016; 16(2): 77-79
    » Abstract

  • Commitment to the wellbeing of children worldwide. [eng]
    Mustafa Abdalla M Salih; Satti Abdelrahim Satti
    Sudan J Paed. 2011; 11(2): 4-5
    » Abstract

  • X-linked hypophosphatemic rickets (PHEX mutation): A case report and literature review.
    Badi Alenazi, M A Maleque Molla, Abdullah Alshaya, Mahmoud Saleh
    Sudan J Paed. 2017; 17(1): 61-65
    » Abstract

  • Bartter syndrome associated with nephropathic cystinosis.
    Nader M Osman, Ali Al Sanosi
    Sudan J Paed. 2016; 16(2): 93-98
    » Abstract

  • The nature and prevalence of psychiatric disorders in a Sudanese juvenile correctional facility.
    Ayaa Siddig Abdelrahman Ali, Mohamed Ali Awadelkarim
    Sudan J Paed. 2016; 16(2): 28-40
    » Abstract

  • Four decades of the Sudanese Journal of Paediatrics and milstones.
    Mustafa Abdalla M Salih, Mohammed Osman Swar
    Sudan J Paed. 2017; 17(1): 5-9
    » Abstract

  • The Editors of Sudanese Journal of Paediatrics would like to thank. [eng]

    Sudan J Paed. 2016; 16(2): 99-99
    » Abstract

  • About the Cover. [eng]

    Sudan J Paed. 2016; 16(2): i-i
    » Abstract

  • Most Downloaded
  • Inborn errors of metabolism associated with hyperglycaemic ketoacidosis and diabetes mellitus: narrative review
    Majid Alfadhel, Amir Babiker
    Sudan J Paed. 2018; 18(1): 10-23
    » Abstract » doi: 10.24911/SJP.2018.1.3

  • Why mothers are not exclusively breast feeding their babies till 6 months of age? Knowledge and practices data from two large cities of the Kingdom of Saudi Arabia
    Hafsa Raheel, Shabana Tharkar
    Sudan J Paed. 2018; 18(1): 28-38
    » Abstract » doi: 10.24911/SJP.2018.1.5

  • Severe desquamation in Kawasaki disease: Is it somehow protective?
    Jubran Theeb Alqanatish, Amir Babiker
    Sudan J Paed. 2017; 17(2): 56-59
    » Abstract » doi: 10.24911/SJP.2017.2.7

  • Burosumab - a new drug to treat hypophosphatemic rickets
    Stepan Kutilek, Amir Babiker, Badi Alenazi
    Sudan J Paed. 2017; 17(2): 71-73
    » Abstract » doi: 10.24911/SJP.2017.2.11

  • Article authored by three generations: International lifetime commitment to child health
    Mustafa Abdalla M Salih, Mohammed Osman Swar
    Sudan J Paed. 2017; 17(2): 5-10
    » Abstract » doi: 10.24911/SJP.2017.2.1

  • Ethical considerations about changing parental attitude towards end-of-life care in twins with lethal disease
    Mohamad-Hani Temsah
    Sudan J Paed. 2018; 18(1): 76-82
    » Abstract » doi: 10.24911/SJP.2018.1.11

  • Congenital brain malformations in Sudanese children: an outpatient-based study
    Inaam Noureldyme Mohammed, Soad Abdalaziz Suliman, Maha A Elseed, Ahlam Abdalrhman Hamed, Mohamed Osman Babiker, Shaimaa Osman Taha
    Sudan J Paed. 2018; 18(1): 48-56
    » Abstract » doi: 10.24911/SJP.2018.1.7

  • Labour Room Continuous Positive Airway Pressure (LR CPAP) in preterm neonates <34 Weeks an Indian experience
    Saumil Ashvinkumar Desai, Pankaj Tule, Ruchi Nimish Nanavati
    Sudan J Paed. 2017; 17(2): 30-34
    » Abstract » doi: 10.24911/SJP.2017.2.3

  • Presacral Neuroblastoma in an 11 months old infant
    Sunil Malik, Sonal Saran, Annu Kharbanda
    Sudan J Paed. 2018; 18(1): 87-89
    » Abstract » doi: 10.24911/SJP.2018.1.14

  • Medical education and services in an extreme environment
    Mustafa Abdalla M. Salih, Mohammed Osman Swar
    Sudan J Paed. 2018; 18(1): 2-5
    » Abstract » doi: 10.24911/SJP.2018.1.1

  • Most Cited Articles
  • Commitment to the wellbeing of children worldwide. [eng]
    Mustafa Abdalla M Salih; Satti Abdelrahim Satti
    Sudan J Paed. 2011; 11(2): 4-5
    » Abstract
    Cited : 4 times [Click to see citing articles]

  • Anti-diabetic medications: How to make a choice?
    Amir Babiker, Mohammed Al Dubayee
    Sudan J Paed. 2017; 17(2): 11-20
    » Abstract » doi: 10.24911/SJP.2017.2.12
    Cited : 2 times [Click to see citing articles]

  • Evaluation of Science. [eng]
    Adnan Mahmmood Usmani; Sultan Ayoub Meo
    Sudan J Paed. 2011; 11(1): 6-7
    » Abstract
    Cited : 1 time [Click to see citing article]

  • Burosumab - a new drug to treat hypophosphatemic rickets
    Stepan Kutilek, Amir Babiker, Badi Alenazi
    Sudan J Paed. 2017; 17(2): 71-73
    » Abstract » doi: 10.24911/SJP.2017.2.11
    Cited : 1 time [Click to see citing article]

  • Inborn errors of metabolism associated with hyperglycaemic ketoacidosis and diabetes mellitus: narrative review
    Majid Alfadhel, Amir Babiker
    Sudan J Paed. 2018; 18(1): 10-23
    » Abstract » doi: 10.24911/SJP.2018.1.3
    Cited : 1 time [Click to see citing article]

  • Pattern of malaria in hospitalized children in Khartoum state
    Hasan Awadalla Hashim, Eltigani Mohamed Ahmed Ali
    Sudan J Paed. 2017; 17(2): 35-41
    » Abstract » doi: 10.24911/SJP.2017.2.4
    Cited : 1 time [Click to see citing article]

  • Why mothers are not exclusively breast feeding their babies till 6 months of age? Knowledge and practices data from two large cities of the Kingdom of Saudi Arabia
    Hafsa Raheel, Shabana Tharkar
    Sudan J Paed. 2018; 18(1): 28-38
    » Abstract » doi: 10.24911/SJP.2018.1.5
    Cited : 1 time [Click to see citing article]

  • Importance of pedigree in patients with familial epilepsy and intellectual disability
    Huseyin Caksen, Fesih Aktar, Gokcen Yildirim, Serdar Ceylaner
    Sudan J Paed. 2019; 19(1): 52-56
    » Abstract » doi: 10.24911/SJP.106-1536222362
    Cited : 1 time [Click to see citing article]

  • Karyotype analysis in children with idiopathic intellectual disability
    Huseyin Caksen, Hayrettin Okut, Mevlit Ikbal
    Sudan J Paed. 2019; 19(1): 57-59
    » Abstract » doi: 10.24911/SJP.106-1539963785
    Cited : 1 time [Click to see citing article]

  • A journey from being preterm to pediatric neurology
    Rana Abdullah AlSheikh, Rawan Abdullah AlSheikh
    Sudan J Paed. 2018; 18(2): 72-73
    » Abstract » doi: 10.24911/SJP.106-1545214668
    Cited : 1 time [Click to see citing article]