E-ISSN 1858-8360 | ISSN 0256-4408
 

Case Report 


Three cases of transient neonatal pseudohypoparathyroidism

Stepan Kutilek, Martina Vracovska, Kamila Pecenkova, Hana Brozikova, Eva Rondzikova, Eliska Boskova, Richard Pikner, Zlata Fejfarkova.

Abstract
Neonatal hypocalcaemia is defined as serum calcium (S-Ca) < 2.0 mmol/L in fullterm newborns and < 1.75 mmol/L in preterm newborns. Neonatal hypocalcaemia is either early onset (<3 days of age) or late onset (>3 days of age). Newborns with hypocalcaemia are often asymptomatic, but may present with hypotonia, apnea, poor feeding, jitteriness, seizures, and cardiac failure. Signs of hypocalcaemia rarely occur unless S-Ca drops below 1.75 mmol/L. Neonatal hypocalcaemia can be a result of hypoparathyroidism (transient or primary), increased serum calcitonin, sepsis, asphyxia, hepatopathy, hypomagnesaemia, high phosphate load, transient hypoparathyroidism, and, rarely, transient neonatal pseudohypoparathyroidism (transient resistance to biological actions of parathyroid hormone [PTH]). We present three boys (two with gestational age 39 weeks, one 36 weeks; none of them with either asphyxia or sepsis) with mild hypotonia, where S-Ca in the range of 1.67-1.9 mmol/L was detected within the first three days of life, together with hyperphosphataemia (serum phosphate [P] 2.5-2.6 mmol/L), normomagnesaemia (serum magnesium [Mg] 0.77-0.88 mmol/L), normal alkaline phosphatase (ALP) activity (2.8-4.5 µkat/L) and high serum PTH (40-51 pg/mL; normal = 5-28). In spite of gradual increase of S-Ca, the elevated serum PTH persisted beyond days 3, 4 and 6 in all three boys, together with normal or low-to-normal S-Ca, high or normal-to-high serum P and no increases in serum ALP. The mothers´ S-Ca, P, Mg, ALP, PTH levels were within normal reference ranges. With regard to laboratory results, the diagnosis of transient neonatal pseudohypoparathyroidism (due to immaturity of PTH-receptors) is highly probable.in these three neonates.

Key words: Calcium; Neonate; Hypocalcaemia; Parathyroid hormone; Pseudohypoparathyroidism


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Stepan Kutilek
Articles by Martina Vracovska
Articles by Kamila Pecenkova
Articles by Hana Brozikova
Articles by Eva Rondzikova
Articles by Eliska Boskova
Articles by Richard Pikner
Articles by Zlata Fejfarkova
on Google
on Google Scholar
Article Statistics
 Viewed: 126
Downloaded: 34
Cited: 0

How to Cite this Article
Pubmed Style

Kutilek S, Vracovska M, Pecenkova K, Brozikova H, Rondzikova E, Boskova E, Pikner R, Fejfarkova Z. Three cases of transient neonatal pseudohypoparathyroidism. Sudan J Paed. 2018; 18(2): 42-47. doi:10.24911/SJP.106-1516889879


Web Style

Kutilek S, Vracovska M, Pecenkova K, Brozikova H, Rondzikova E, Boskova E, Pikner R, Fejfarkova Z. Three cases of transient neonatal pseudohypoparathyroidism. http://www.sudanjp.com/?mno=289314 [Access: January 17, 2019]. doi:10.24911/SJP.106-1516889879


AMA (American Medical Association) Style

Kutilek S, Vracovska M, Pecenkova K, Brozikova H, Rondzikova E, Boskova E, Pikner R, Fejfarkova Z. Three cases of transient neonatal pseudohypoparathyroidism. Sudan J Paed. 2018; 18(2): 42-47. doi:10.24911/SJP.106-1516889879



Vancouver/ICMJE Style

Kutilek S, Vracovska M, Pecenkova K, Brozikova H, Rondzikova E, Boskova E, Pikner R, Fejfarkova Z. Three cases of transient neonatal pseudohypoparathyroidism. Sudan J Paed. (2018), [cited January 17, 2019]; 18(2): 42-47. doi:10.24911/SJP.106-1516889879



Harvard Style

Kutilek, S., Vracovska, . M., Pecenkova, . K., Brozikova, . H., Rondzikova, . E., Boskova, . E., Pikner, . R. & Fejfarkova, . Z. (2018) Three cases of transient neonatal pseudohypoparathyroidism. Sudan J Paed, 18 (2), 42-47. doi:10.24911/SJP.106-1516889879



Turabian Style

Kutilek, Stepan, Martina Vracovska, Kamila Pecenkova, Hana Brozikova, Eva Rondzikova, Eliska Boskova, Richard Pikner, and Zlata Fejfarkova. 2018. Three cases of transient neonatal pseudohypoparathyroidism. Sudanese Journal of Paediatrics, 18 (2), 42-47. doi:10.24911/SJP.106-1516889879



Chicago Style

Kutilek, Stepan, Martina Vracovska, Kamila Pecenkova, Hana Brozikova, Eva Rondzikova, Eliska Boskova, Richard Pikner, and Zlata Fejfarkova. "Three cases of transient neonatal pseudohypoparathyroidism." Sudanese Journal of Paediatrics 18 (2018), 42-47. doi:10.24911/SJP.106-1516889879



MLA (The Modern Language Association) Style

Kutilek, Stepan, Martina Vracovska, Kamila Pecenkova, Hana Brozikova, Eva Rondzikova, Eliska Boskova, Richard Pikner, and Zlata Fejfarkova. "Three cases of transient neonatal pseudohypoparathyroidism." Sudanese Journal of Paediatrics 18.2 (2018), 42-47. Print. doi:10.24911/SJP.106-1516889879



APA (American Psychological Association) Style

Kutilek, S., Vracovska, . M., Pecenkova, . K., Brozikova, . H., Rondzikova, . E., Boskova, . E., Pikner, . R. & Fejfarkova, . Z. (2018) Three cases of transient neonatal pseudohypoparathyroidism. Sudanese Journal of Paediatrics, 18 (2), 42-47. doi:10.24911/SJP.106-1516889879





Most Viewed Articles
  • Blood tests are not always helpful in predicting bacterial meningitis in children.
    Taha I Yousif, Katie O'Reilly, Montasser Nadeem
    Sudan J Paed. 2016; 16(2): 77-79
    » Abstract

  • Evaluation of Science. [eng]
    Adnan Mahmmood Usmani; Sultan Ayoub Meo
    Sudan J Paed. 2011; 11(1): 6-7
    » Abstract

  • Commitment to the wellbeing of children worldwide. [eng]
    Mustafa Abdalla M Salih; Satti Abdelrahim Satti
    Sudan J Paed. 2011; 11(2): 4-5
    » Abstract

  • X-linked hypophosphatemic rickets (PHEX mutation): A case report and literature review.
    Badi Alenazi, M A Maleque Molla, Abdullah Alshaya, Mahmoud Saleh
    Sudan J Paed. 2017; 17(1): 61-65
    » Abstract

  • About the Cover. [eng]

    Sudan J Paed. 2016; 16(2): i-i
    » Abstract

  • Four decades of the Sudanese Journal of Paediatrics and milstones.
    Mustafa Abdalla M Salih, Mohammed Osman Swar
    Sudan J Paed. 2017; 17(1): 5-9
    » Abstract

  • The nature and prevalence of psychiatric disorders in a Sudanese juvenile correctional facility.
    Ayaa Siddig Abdelrahman Ali, Mohamed Ali Awadelkarim
    Sudan J Paed. 2016; 16(2): 28-40
    » Abstract

  • Bartter syndrome associated with nephropathic cystinosis.
    Nader M Osman, Ali Al Sanosi
    Sudan J Paed. 2016; 16(2): 93-98
    » Abstract

  • The Editors of Sudanese Journal of Paediatrics would like to thank. [eng]

    Sudan J Paed. 2016; 16(2): 99-99
    » Abstract

  • Article authored by three generations: International lifetime commitment to child health
    Mustafa Abdalla M Salih, Mohammed Osman Swar
    Sudan J Paed. 2017; 17(2): 5-10
    » Abstract » doi: 10.24911/SJP.2017.2.1

  • Most Downloaded
  • Inborn errors of metabolism associated with hyperglycaemic ketoacidosis and diabetes mellitus: narrative review
    Majid Alfadhel, Amir Babiker
    Sudan J Paed. 2018; 18(1): 10-23
    » Abstract » doi: 10.24911/SJP.2018.1.3

  • Why mothers are not exclusively breast feeding their babies till 6 months of age? Knowledge and practices data from two large cities of the Kingdom of Saudi Arabia
    Hafsa Raheel, Shabana Tharkar
    Sudan J Paed. 2018; 18(1): 28-38
    » Abstract » doi: 10.24911/SJP.2018.1.5

  • Burosumab - a new drug to treat hypophosphatemic rickets
    Stepan Kutilek, Amir Babiker, Badi Alenazi
    Sudan J Paed. 2017; 17(2): 71-73
    » Abstract » doi: 10.24911/SJP.2017.2.11

  • Article authored by three generations: International lifetime commitment to child health
    Mustafa Abdalla M Salih, Mohammed Osman Swar
    Sudan J Paed. 2017; 17(2): 5-10
    » Abstract » doi: 10.24911/SJP.2017.2.1

  • Ethical considerations about changing parental attitude towards end-of-life care in twins with lethal disease
    Mohamad-Hani Temsah
    Sudan J Paed. 2018; 18(1): 76-82
    » Abstract » doi: 10.24911/SJP.2018.1.11

  • Severe desquamation in Kawasaki disease: Is it somehow protective?
    Jubran Theeb Alqanatish, Amir Babiker
    Sudan J Paed. 2017; 17(2): 56-59
    » Abstract » doi: 10.24911/SJP.2017.2.7

  • Medical education and services in an extreme environment
    Mustafa Abdalla M. Salih, Mohammed Osman Swar
    Sudan J Paed. 2018; 18(1): 2-5
    » Abstract » doi: 10.24911/SJP.2018.1.1

  • Congenital brain malformations in Sudanese children: an outpatient-based study
    Inaam Noureldyme Mohammed, Soad Abdalaziz Suliman, Maha A Elseed, Ahlam Abdalrhman Hamed, Mohamed Osman Babiker, Shaimaa Osman Taha
    Sudan J Paed. 2018; 18(1): 48-56
    » Abstract » doi: 10.24911/SJP.2018.1.7

  • Presacral Neuroblastoma in an 11 months old infant
    Sunil Malik, Sonal Saran, Annu Kharbanda
    Sudan J Paed. 2018; 18(1): 87-89
    » Abstract » doi: 10.24911/SJP.2018.1.14

  • The relationship between birth weight and congenital heart disease at Ahmed Gasim Cardiac Centre, Bahri, Sudan
    Hafiz Osama Hafiz Elshazali, Osama Hafiz Elshazali, Hafiz Elshazali
    Sudan J Paed. 2017; 17(2): 49-55
    » Abstract » doi: 10.24911/SJP.2017.2.6

  • Most Cited Articles
  • Commitment to the wellbeing of children worldwide. [eng]
    Mustafa Abdalla M Salih; Satti Abdelrahim Satti
    Sudan J Paed. 2011; 11(2): 4-5
    » Abstract
    Cited : 4 times [Click to see citing articles]

  • Evaluation of Science. [eng]
    Adnan Mahmmood Usmani; Sultan Ayoub Meo
    Sudan J Paed. 2011; 11(1): 6-7
    » Abstract
    Cited : 1 time [Click to see citing article]

  • Burosumab - a new drug to treat hypophosphatemic rickets
    Stepan Kutilek, Amir Babiker, Badi Alenazi
    Sudan J Paed. 2017; 17(2): 71-73
    » Abstract » doi: 10.24911/SJP.2017.2.11
    Cited : 1 time [Click to see citing article]