E-ISSN 1858-8360 | ISSN 0256-4408
 

Original Research (Original Article) 


Childhood nephrotic syndrome at the University of Abuja Teaching Hospital, Abuja, Nigeria: a preliminary report supports high steroid responsiveness

Emmanuel Ademola Anigilaje, Andrew Fashie, Clement Ochi.

Abstract
The response to steroid in childhood nephrotic syndrome (CNS) varies across geographical regions, depending on aetiology, genetics, and the underlying pathology. Recently, there is an increasing steroid responsiveness among Nigerian children with nephrotic syndrome (NS). This is the first report of CNS at the University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria, between 15th January 2016 and 30th June 2018. Prednisolone was administered to all the children with NS according to the regimen of the International Study of Kidney Disease in Children. There were 46 children aged 17 months to 18 years, including 37 males and 9 females. The peak age was 6–10 years with a mean age of 8.2 ± 4.4 years. Forty-one (89.1%) had idiopathic NS (INS). Secondary NS occurred in five (10.9%) children with hepatitis B infection, sickle cell anaemia, haemolytic-uraemic syndrome, and post-infectious glomerulonephritis (two cases). Plasmodium malariae was not seen. Overall, steroid-sensitive NS (SSNS) was seen in 34 (73.9%) and in 32 (78%) with INS. Five (16.7%) of the 30 with SSNS relapsed on follow-up. Twelve (26.1%) were resistant to steroid (steroid-resistant NS, SRNS). Renal biopsies in five SRNS revealed focal segmental glomerulosclerosis in three, minimal change
lesion in one, and severe interstitial fibrosis/glomerulosclerosis in another one. Four (8.7%) children who had SRNS died. A child with SRNS is surviving on renal transplant from a living-unrelated donor. The study supports the notion that steroid responsiveness is increasing among ethnic black Nigerian children. Pre-treatment renal biopsy may be unwarranted.

Key words: Childhood nephrotic syndrome; Steroid responsiveness; Abuja; Nigeria.


 
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How to Cite this Article
Pubmed Style

Anigilaje EA, Fashie A, Ochi C, . Childhood nephrotic syndrome at the University of Abuja Teaching Hospital, Abuja, Nigeria: a preliminary report supports high steroid responsiveness. Sudan J Paed. 2019; 19(2): 126-139. doi:10.24911/SJP.106-1547399573


Web Style

Anigilaje EA, Fashie A, Ochi C, . Childhood nephrotic syndrome at the University of Abuja Teaching Hospital, Abuja, Nigeria: a preliminary report supports high steroid responsiveness. http://www.sudanjp.com/?mno=25975 [Access: February 28, 2020]. doi:10.24911/SJP.106-1547399573


AMA (American Medical Association) Style

Anigilaje EA, Fashie A, Ochi C, . Childhood nephrotic syndrome at the University of Abuja Teaching Hospital, Abuja, Nigeria: a preliminary report supports high steroid responsiveness. Sudan J Paed. 2019; 19(2): 126-139. doi:10.24911/SJP.106-1547399573



Vancouver/ICMJE Style

Anigilaje EA, Fashie A, Ochi C, . Childhood nephrotic syndrome at the University of Abuja Teaching Hospital, Abuja, Nigeria: a preliminary report supports high steroid responsiveness. Sudan J Paed. (2019), [cited February 28, 2020]; 19(2): 126-139. doi:10.24911/SJP.106-1547399573



Harvard Style

Anigilaje, E. A., Fashie, A., Ochi, C. & (2019) Childhood nephrotic syndrome at the University of Abuja Teaching Hospital, Abuja, Nigeria: a preliminary report supports high steroid responsiveness. Sudan J Paed, 19 (2), 126-139. doi:10.24911/SJP.106-1547399573



Turabian Style

Anigilaje, Emmanuel Ademola, Andrew Fashie, Clement Ochi, and . 2019. Childhood nephrotic syndrome at the University of Abuja Teaching Hospital, Abuja, Nigeria: a preliminary report supports high steroid responsiveness. Sudanese Journal of Paediatrics, 19 (2), 126-139. doi:10.24911/SJP.106-1547399573



Chicago Style

Anigilaje, Emmanuel Ademola, Andrew Fashie, Clement Ochi, and . "Childhood nephrotic syndrome at the University of Abuja Teaching Hospital, Abuja, Nigeria: a preliminary report supports high steroid responsiveness." Sudanese Journal of Paediatrics 19 (2019), 126-139. doi:10.24911/SJP.106-1547399573



MLA (The Modern Language Association) Style

Anigilaje, Emmanuel Ademola, Andrew Fashie, Clement Ochi, and . "Childhood nephrotic syndrome at the University of Abuja Teaching Hospital, Abuja, Nigeria: a preliminary report supports high steroid responsiveness." Sudanese Journal of Paediatrics 19.2 (2019), 126-139. Print. doi:10.24911/SJP.106-1547399573



APA (American Psychological Association) Style

Anigilaje, E. A., Fashie, A., Ochi, C. & (2019) Childhood nephrotic syndrome at the University of Abuja Teaching Hospital, Abuja, Nigeria: a preliminary report supports high steroid responsiveness. Sudanese Journal of Paediatrics, 19 (2), 126-139. doi:10.24911/SJP.106-1547399573





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