E-ISSN 1858-8360 | ISSN 0256-4408
 

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SUDANESE JOURNAL OF PAEDIATRICS

2018; Vol 18, Issue No. 2

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Imaging features of complete agenesis of corpus callosum in a 3-year-old child

Sunil Malik (1), Sonal Saran (2), Yash Sharma (2), Anna Kharbanda (2)

(1) Department of Pediatrics, Subharti Medical College, Meerut, India

(2) Department of Radiology, Subharti Medical College, Meerut, India

Correspondence to:

Sonal Saran

Flat No 6, X block, Subhartipuram, Subharti Medical College, Meerut 250005, 8239115800, India.

Email: Sonalsaranmalik [at] gmail.com

Received: 10 April 2018 | Accepted: 19 November 2018

How to cite this article:

Malik S, Saran S, Sharma Y, Kharbanda A. Imaging features of complete agenesis of corpus callosum in a 3-year-old child. Sudan J Paediatr. 2018;18(2):69–71.

https://doi.org/10.24911/SJP.106-1523336915


A 3-year-old male child presented to the Pediatric Outpatient Department with history of gross developmental delay. He was the product of normal vaginal delivery with an immediate cry at birth. Antenatal history of the mother was also insignificant. Table 1 shows a summary of the developmental milestones checklist of the child.

The patient was referred to the Department of Radiology for magnetic resonance imaging (MRI) of brain. Features of brain MRI included parallel running prominent bilateral lateral ventricles with complete absence of corpus callosum (Figure 1a), and colpocephaly, i.e., dilatation of the occipital horns of lateral ventricles (Figure 1b). The mid-sagittal image showed the radial arrangement of the gyri (Figure 2). Coronal images showed widely spaced lateral ventricles giving a characteristic “moose head/Viking helmet sign” (Figure 3).

Dysgenesis of the corpus callosum can be partial or complete and can be primary (corpus callosum never formed) or secondary (corpus callosum secondarily destroyed after normal formation). The affected patients are mostly asymptomatic. Maternal alcohol consumption during pregnancy is a recognized risk factor, and males predominate over females. Agenesis of the corpus callosum is often associated with a number of aneuploidy and non-aneuploidy syndromes. It is also associated with other central nervous system malformations. The prognosis of the patient depends on the associated anomalies and treatment includes conservative management with rehabilitation [1,2].

Table 1 - Developmental milestones of the patient

Gross motor milestones Normally achieved at Status
Neck holding 3–4 months Not achieved
Rolling over 6 months Not achieved
Sitting with support 6 months Not achieved
Sitting without support 8 months Not achieved
Stands with support 10 months Not achieved
Stands without support 12 months Not achieved
Fine motor milestones Normally achieved at Status
Bidextrous reach for objects 4 months Not achieved
Unidextrous reach for objects 6 months Not achieved
Immature pincer grasp 9 months Not achieved
Social milestones Normally achieved at Status
Social smile 2 months 6 months
Recognize mother 3 months 6 months
Stranger anxiety 6 months 2 years
Waves bye bye 9 months Not achieved
Alert to sound 1 month 6 months
Babbles and coos 3 months 1 year
Loud laughs and turn toward the sound 4 months 1 year
Monosyllables 6 months Not achieved
Bisyllables 9 months Not achieved

Figure 1 - Brain MRI T2-weighted axial sequence showing (a) widely spaced prominent lateral ventricles (star) and (b) complete absence of corpus callosum in midline (double arrow) with colpocephaly, i.e., dilated occipital horns of lateral ventricles (triangles).

Figure 2 - Brain MRI T2-weighted sagittal sequence showing complete absence of corpus callosum with radial arrangement of cerebral gyri giving sunburst appearance (arrows).

Figure 3 - Brain MRI T2-weighted coronal sequence showing widely spaced lateral ventricles depicting a characteristic “moose head/Viking helmet sign.”


REFERENCES

  1. Tang PH, Bartha AI, Norton ME, Barkovich AJ, Sherr EH, Glenn OA. Agenesis of the corpus callosum: an MR imaging analysis of associated abnormalities in the fetus. AJNR Am J Neuroradiol. 2009;30(2):257–63; https://doi.org/10.3174/ajnr.A1331
  2. Dávila-Gutiérrez G. Agenesis and dysgenesis of the corpus callosum. Semin Pediatr Neurol. 2002;9(4):292–301; https://doi.org/10.1053/spen.2002.32505


How to Cite this Article
Pubmed Style

Malik S, Saran S, sharma y, Kharbanda A. Imaging features of complete agenesis of corpus callosum in a 3-year-old child. Sudan J Paed. 2018; 18(2): 69-71. doi:10.24911/SJP.106-1523336915


Web Style

Malik S, Saran S, sharma y, Kharbanda A. Imaging features of complete agenesis of corpus callosum in a 3-year-old child. http://www.sudanjp.com/?mno=296185 [Access: February 18, 2019]. doi:10.24911/SJP.106-1523336915


AMA (American Medical Association) Style

Malik S, Saran S, sharma y, Kharbanda A. Imaging features of complete agenesis of corpus callosum in a 3-year-old child. Sudan J Paed. 2018; 18(2): 69-71. doi:10.24911/SJP.106-1523336915



Vancouver/ICMJE Style

Malik S, Saran S, sharma y, Kharbanda A. Imaging features of complete agenesis of corpus callosum in a 3-year-old child. Sudan J Paed. (2018), [cited February 18, 2019]; 18(2): 69-71. doi:10.24911/SJP.106-1523336915



Harvard Style

Malik, S., Saran, . S., sharma, . y. & Kharbanda, . A. (2018) Imaging features of complete agenesis of corpus callosum in a 3-year-old child. Sudan J Paed, 18 (2), 69-71. doi:10.24911/SJP.106-1523336915



Turabian Style

Malik, Sunil, Sonal Saran, yash sharma, and Annu Kharbanda. 2018. Imaging features of complete agenesis of corpus callosum in a 3-year-old child. Sudanese Journal of Paediatrics, 18 (2), 69-71. doi:10.24911/SJP.106-1523336915



Chicago Style

Malik, Sunil, Sonal Saran, yash sharma, and Annu Kharbanda. "Imaging features of complete agenesis of corpus callosum in a 3-year-old child." Sudanese Journal of Paediatrics 18 (2018), 69-71. doi:10.24911/SJP.106-1523336915



MLA (The Modern Language Association) Style

Malik, Sunil, Sonal Saran, yash sharma, and Annu Kharbanda. "Imaging features of complete agenesis of corpus callosum in a 3-year-old child." Sudanese Journal of Paediatrics 18.2 (2018), 69-71. Print. doi:10.24911/SJP.106-1523336915



APA (American Psychological Association) Style

Malik, S., Saran, . S., sharma, . y. & Kharbanda, . A. (2018) Imaging features of complete agenesis of corpus callosum in a 3-year-old child. Sudanese Journal of Paediatrics, 18 (2), 69-71. doi:10.24911/SJP.106-1523336915





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