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2025, Vol: 25, Issue: 2
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Case Report
Online Published: 02 Jan 2026
 


Lopsided brain: A Case of hemispheric dysplasia with cortical malformation in an infant

Rekha Gupta Rekha, Chandrika Sachar Chandrika, Sanjeev Jindal Sanjeev, Chandrika Azad Chandrika.


Abstract
Cortical development malformations result from disruptions in neuronal migration, leading to a spectrum of brain abnormalities with significant clinical implications. This case report presents a 1-year-old male with hemiplegic cerebral palsy, without a history of seizures—an atypical presentation for cortical migration disorders. Brain magnetic resonance imaging (MRI) revealed extensive cortical abnormalities, including features of focal cortical dysplasia (FCD), polymicrogyria, and subcortical heterotopia, along with asymmetric hemispheric changes suggestive of hemispheric dysplasia rather than classical hemimegalencephaly (HME). The imaging findings were crucial in differentiating between overlapping entities such as hemimegalencephaly, and hemispheric dysplasia. This case emphasizes the pivotal role of early neuroimaging in evaluating infants with neurological deficits, even when seizures are not present, and highlights the importance of a detailed and individualized approach to diagnosing intricate cortical malformations.

Key words: Cortical migration disorder, Hemispheric dysplasia, Polymicrogyria/pachygyria, Subcortical heterotopia, Focal cortical dysplasia, Infant, Magnetic resonance imaging.


 
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How to Cite this Article
Pubmed Style

Rekha RG, Chandrika CS, Sanjeev SJ, Chandrika CA. Lopsided brain: A Case of hemispheric dysplasia with cortical malformation in an infant. Sudan J Paed. 2025; 25(2): 152-156. doi:10.24911/SJP.106-1744986519

Web Style

Rekha RG, Chandrika CS, Sanjeev SJ, Chandrika CA. Lopsided brain: A Case of hemispheric dysplasia with cortical malformation in an infant. https://sudanjp.com//?mno=253326 [Access: February 05, 2026]. doi:10.24911/SJP.106-1744986519

AMA (American Medical Association) Style

Rekha RG, Chandrika CS, Sanjeev SJ, Chandrika CA. Lopsided brain: A Case of hemispheric dysplasia with cortical malformation in an infant. Sudan J Paed. 2025; 25(2): 152-156. doi:10.24911/SJP.106-1744986519


Vancouver/ICMJE Style

Rekha RG, Chandrika CS, Sanjeev SJ, Chandrika CA. Lopsided brain: A Case of hemispheric dysplasia with cortical malformation in an infant. Sudan J Paed. (2025), [cited February 05, 2026]; 25(2): 152-156. doi:10.24911/SJP.106-1744986519


Harvard Style

Rekha, R. G., Chandrika, . C. S., Sanjeev, . S. J. & Chandrika, . C. A. (2025) Lopsided brain: A Case of hemispheric dysplasia with cortical malformation in an infant. Sudan J Paed, 25 (2), 152-156. doi:10.24911/SJP.106-1744986519


Turabian Style

Rekha, Rekha Gupta, Chandrika Sachar Chandrika, Sanjeev Jindal Sanjeev, and Chandrika Azad Chandrika. 2025. Lopsided brain: A Case of hemispheric dysplasia with cortical malformation in an infant. Sudanese Journal of Paediatrics, 25 (2), 152-156. doi:10.24911/SJP.106-1744986519


Chicago Style

Rekha, Rekha Gupta, Chandrika Sachar Chandrika, Sanjeev Jindal Sanjeev, and Chandrika Azad Chandrika. "Lopsided brain: A Case of hemispheric dysplasia with cortical malformation in an infant." Sudanese Journal of Paediatrics 25 (2025), 152-156. doi:10.24911/SJP.106-1744986519


MLA (The Modern Language Association) Style

Rekha, Rekha Gupta, Chandrika Sachar Chandrika, Sanjeev Jindal Sanjeev, and Chandrika Azad Chandrika. "Lopsided brain: A Case of hemispheric dysplasia with cortical malformation in an infant." Sudanese Journal of Paediatrics 25.2 (2025), 152-156. Print. doi:10.24911/SJP.106-1744986519


APA (American Psychological Association) Style

Rekha, R. G., Chandrika, . C. S., Sanjeev, . S. J. & Chandrika, . C. A. (2025) Lopsided brain: A Case of hemispheric dysplasia with cortical malformation in an infant. Sudanese Journal of Paediatrics, 25 (2), 152-156. doi:10.24911/SJP.106-1744986519




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