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Case Report
Online Published: 28 Dec 2025
 


Ornidazole neurotoxic footprint: A comprehensive pediatric case report with follow up imaging

Chandrika Sachar, Purnima Aggarwal.


Abstract
Nitroimidazoles, such as metronidazole and ornidazole, are widely used in pediatric patients, yet rare cases of ornidazole neurotoxicity have been reported. We present a 7-year-old boy who developed acute weakness, ataxia, and slurred speech after taking over-the-counter tablet containing ornidazole drug for abdominal pain and diarrhea. Magnetic resonance imaging (MRI) showed symmetrical hyperintensities in the dentate nuclei, indicating possible demyelinating or toxic condition. Ornidazole-induced neurotoxicity was confirmed based on clinical history and improvement upon drug discontinuation. Follow-up MRI after two months showed near-complete resolution. This case highlights the importance of recognizing ornidazole toxicity, understanding its specific imaging characteristics, and emphasizes the need for early diagnosis and careful medication review to avoid unnecessary investigations.

Key words: Ornidazole, Cerebellar ataxia, Pediatric, Dentate nucleus.


 
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Pubmed Style

Sachar C, Aggarwal P. Ornidazole neurotoxic footprint: A comprehensive pediatric case report with follow up imaging. Sudan J Paed. 2025; 25(2): 157-162. doi:10.24911/SJP.106-1744643325

Web Style

Sachar C, Aggarwal P. Ornidazole neurotoxic footprint: A comprehensive pediatric case report with follow up imaging. https://sudanjp.com//?mno=252637 [Access: February 05, 2026]. doi:10.24911/SJP.106-1744643325

AMA (American Medical Association) Style

Sachar C, Aggarwal P. Ornidazole neurotoxic footprint: A comprehensive pediatric case report with follow up imaging. Sudan J Paed. 2025; 25(2): 157-162. doi:10.24911/SJP.106-1744643325


Vancouver/ICMJE Style

Sachar C, Aggarwal P. Ornidazole neurotoxic footprint: A comprehensive pediatric case report with follow up imaging. Sudan J Paed. (2025), [cited February 05, 2026]; 25(2): 157-162. doi:10.24911/SJP.106-1744643325


Harvard Style

Sachar, C. & Aggarwal, . P. (2025) Ornidazole neurotoxic footprint: A comprehensive pediatric case report with follow up imaging. Sudan J Paed, 25 (2), 157-162. doi:10.24911/SJP.106-1744643325


Turabian Style

Sachar, Chandrika, and Purnima Aggarwal. 2025. Ornidazole neurotoxic footprint: A comprehensive pediatric case report with follow up imaging. Sudanese Journal of Paediatrics, 25 (2), 157-162. doi:10.24911/SJP.106-1744643325


Chicago Style

Sachar, Chandrika, and Purnima Aggarwal. "Ornidazole neurotoxic footprint: A comprehensive pediatric case report with follow up imaging." Sudanese Journal of Paediatrics 25 (2025), 157-162. doi:10.24911/SJP.106-1744643325


MLA (The Modern Language Association) Style

Sachar, Chandrika, and Purnima Aggarwal. "Ornidazole neurotoxic footprint: A comprehensive pediatric case report with follow up imaging." Sudanese Journal of Paediatrics 25.2 (2025), 157-162. Print. doi:10.24911/SJP.106-1744643325


APA (American Psychological Association) Style

Sachar, C. & Aggarwal, . P. (2025) Ornidazole neurotoxic footprint: A comprehensive pediatric case report with follow up imaging. Sudanese Journal of Paediatrics, 25 (2), 157-162. doi:10.24911/SJP.106-1744643325




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