E-ISSN 1858-8360 | ISSN 0256-4408
 

Original Article 


Aetiologies and clinical patterns of hypopituitarism in Sudanese children

Samar S. Hassan, Renson Mukhwana, Salwa Musa, Areej A. B. Ibrahim, Omer Babiker, Mohamed A. Abdullah.

Abstract
There is paucity of reported information regarding aetiology and clinical profile of hypopituitarism from resource-limited countries particularly in populations with high rates of consanguineous marriages. Here, we are reporting the first data on this aspect from Sudan. This is a descriptive, retrospective, hospital-based study, carried out in the two main paediatric endocrinology centres in
Sudan (Gafaar Ibn Auf Paediatric Tertiary Hospital and Soba University Hospital, Khartoum) from January 2006 up to December 2014. Patientsí records were reviewed for relevant demographical, clinical, hormonal and radiological data using pretested study
forms. The study included 156 patients. One hundred and one patients were males (M: F = 1.8:1). The commonest age groups were
adolescents (57.7%). Consanguinity was found in 77.8% of patients overall and 91% of patients with congenital aetiologies. The commonest clinical presentation was short stature (93.5%). Congenital causes (86.5%) were more prevalent than acquired causes
(13.5%). There were six family clusters with multiple pituitary hormone deficiencies (MPHD) and three families with isolated
growth hormone (GH) deficiency (IGHD). Most of the congenital cases with MPHD were phenotypic for PROP1 gene mutation (77.5% of sporadic cases and 50% of familial cases). Craniopharyngioma was the commonest of the acquired causes (10.2%). GH was the most frequent hormone deficient (89.7%). Abnormal Magnetic resonance imaging brain findings were significantly seen more in MPHD in comparison to IGHD. The genetic forms of hypopituitarism in populations with high rates of consanguineous marriage like Sudan may be higher than those reported internationally. Molecular genetic studies are, therefore, highly recommended.

Key words: Multiple pituitary hormone deficiency; Isolated growth hormone deficiency; Hypopituitarism; Children; Sudan.


 
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How to Cite this Article
Pubmed Style

Hassan SS, Mukhwana R, Musa S, Ibrahim AAB, Babiker O, Abdullah MA. Aetiologies and clinical patterns of hypopituitarism in Sudanese children. Sudan J Paed. 2021; 21(1): 53-60. doi:10.24911/SJP.106-1588448825


Web Style

Hassan SS, Mukhwana R, Musa S, Ibrahim AAB, Babiker O, Abdullah MA. Aetiologies and clinical patterns of hypopituitarism in Sudanese children. http://www.sudanjp.com/?mno=103965 [Access: April 08, 2021]. doi:10.24911/SJP.106-1588448825


AMA (American Medical Association) Style

Hassan SS, Mukhwana R, Musa S, Ibrahim AAB, Babiker O, Abdullah MA. Aetiologies and clinical patterns of hypopituitarism in Sudanese children. Sudan J Paed. 2021; 21(1): 53-60. doi:10.24911/SJP.106-1588448825



Vancouver/ICMJE Style

Hassan SS, Mukhwana R, Musa S, Ibrahim AAB, Babiker O, Abdullah MA. Aetiologies and clinical patterns of hypopituitarism in Sudanese children. Sudan J Paed. (2021), [cited April 08, 2021]; 21(1): 53-60. doi:10.24911/SJP.106-1588448825



Harvard Style

Hassan, S. S., Mukhwana, . R., Musa, . S., Ibrahim, . A. A. B., Babiker, . O. & Abdullah, . M. A. (2021) Aetiologies and clinical patterns of hypopituitarism in Sudanese children. Sudan J Paed, 21 (1), 53-60. doi:10.24911/SJP.106-1588448825



Turabian Style

Hassan, Samar S., Renson Mukhwana, Salwa Musa, Areej A. B. Ibrahim, Omer Babiker, and Mohamed A. Abdullah. 2021. Aetiologies and clinical patterns of hypopituitarism in Sudanese children. Sudanese Journal of Paediatrics, 21 (1), 53-60. doi:10.24911/SJP.106-1588448825



Chicago Style

Hassan, Samar S., Renson Mukhwana, Salwa Musa, Areej A. B. Ibrahim, Omer Babiker, and Mohamed A. Abdullah. "Aetiologies and clinical patterns of hypopituitarism in Sudanese children." Sudanese Journal of Paediatrics 21 (2021), 53-60. doi:10.24911/SJP.106-1588448825



MLA (The Modern Language Association) Style

Hassan, Samar S., Renson Mukhwana, Salwa Musa, Areej A. B. Ibrahim, Omer Babiker, and Mohamed A. Abdullah. "Aetiologies and clinical patterns of hypopituitarism in Sudanese children." Sudanese Journal of Paediatrics 21.1 (2021), 53-60. Print. doi:10.24911/SJP.106-1588448825



APA (American Psychological Association) Style

Hassan, S. S., Mukhwana, . R., Musa, . S., Ibrahim, . A. A. B., Babiker, . O. & Abdullah, . M. A. (2021) Aetiologies and clinical patterns of hypopituitarism in Sudanese children. Sudanese Journal of Paediatrics, 21 (1), 53-60. doi:10.24911/SJP.106-1588448825





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