Vitamin K deficiency bleeding of newborn masquerading haemophilia B

Mritunjay Kumar; Sidharth Kumar; Shivani Bajpayi; Rashmi Kumari

doi:10.24911/SJP.106-1584209747

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Sudan J Paed. 2020; 20(2): 176-180

doi: 10.24911/SJP.106-1584209747

Vitamin K deficiency bleeding of newborn masquerading haemophilia B

Mritunjay Kumar, Sidharth Kumar, Shivani Bajpayi, Rashmi Kumari.

Abstract
The term infant is remarkably resistant to bleeding despite physiologically low levels of procoagulant proteins. However, because of their unique haemostatic systems, neonates are vulnerable to haemorrhagic disorders. The prevention of early vitamin K deficiency bleeding (VKDB) of newborn by oral or parenteral administration of vitamin K has been well established. However, rarely, a newborn can present with bleeding manifestations even after routine vitamin K prophylaxis at birth. A 2-day-old healthy male baby presented with catastrophic pulmonary haemorrhage with severely deranged coagulation profile even after receiving vitamin K prophylaxis at birth. His presentation, initial laboratory findings and course in the hospital were very much in favour of haemophilia B, but follow-up factor IX level and clinical exome sequencing did not confirm it. However, protein induced in vitamin K absence-II was found to be raised just before the discharge, and we concluded this case as a rare presentation of classical VKDB.

Key words: Newborn; Bleeding; Vitamin K deficiency bleeding (VKDB); Protein induced in vitamin K absence-II (PIVKA-II); Haemophilia.

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Pubmed Style

Kumar M, Kumar S, Bajpayi S, Kumari R. Vitamin K deficiency bleeding of newborn masquerading haemophilia B. Sudan J Paed. 2020; 20(2): 176-180. doi:10.24911/SJP.106-1584209747

Web Style

Kumar M, Kumar S, Bajpayi S, Kumari R. Vitamin K deficiency bleeding of newborn masquerading haemophilia B. https://sudanjp.com//?mno=92551 [Access: June 22, 2024]. doi:10.24911/SJP.106-1584209747

AMA (American Medical Association) Style

Kumar M, Kumar S, Bajpayi S, Kumari R. Vitamin K deficiency bleeding of newborn masquerading haemophilia B. Sudan J Paed. 2020; 20(2): 176-180. doi:10.24911/SJP.106-1584209747

Vancouver/ICMJE Style

Kumar M, Kumar S, Bajpayi S, Kumari R. Vitamin K deficiency bleeding of newborn masquerading haemophilia B. Sudan J Paed. (2020), [cited June 22, 2024]; 20(2): 176-180. doi:10.24911/SJP.106-1584209747

Harvard Style

Kumar, M., Kumar, . S., Bajpayi, . S. & Kumari, . R. (2020) Vitamin K deficiency bleeding of newborn masquerading haemophilia B. Sudan J Paed, 20 (2), 176-180. doi:10.24911/SJP.106-1584209747

Turabian Style

Kumar, Mritunjay, Sidharth Kumar, Shivani Bajpayi, and Rashmi Kumari. 2020. Vitamin K deficiency bleeding of newborn masquerading haemophilia B. Sudanese Journal of Paediatrics, 20 (2), 176-180. doi:10.24911/SJP.106-1584209747

Chicago Style

Kumar, Mritunjay, Sidharth Kumar, Shivani Bajpayi, and Rashmi Kumari. "Vitamin K deficiency bleeding of newborn masquerading haemophilia B." Sudanese Journal of Paediatrics 20 (2020), 176-180. doi:10.24911/SJP.106-1584209747

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Kumar, M., Kumar, . S., Bajpayi, . S. & Kumari, . R. (2020) Vitamin K deficiency bleeding of newborn masquerading haemophilia B. Sudanese Journal of Paediatrics, 20 (2), 176-180. doi:10.24911/SJP.106-1584209747

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